Renato Corradetti

Biography

Renato Corradetti graduated in Medicine and Surgery (1977) and specialized in Neurology (1982) at the University of Florence. Confirmed Researcher (1981-1992), Associate Professor of Pharmacology (1992-2001). Since 2001 he is Professor of Pharmacology. Experience of her field of research is the pharmacological modulation of neurotransmission and long-term potentiation (LTP) in the SNC using electrophysiological (in vitro) and neurochemical methods, often associated with it. He studied the role of numerous neurotransmitters (adenosine, 5-HT, glutamate and GABA) in hippocampal neurotransmission in adult rats, but also during developmental and / or pathological conditions (similarity, anoxia). He studied in detail the electrophysiological and neurochemical correlates, as well as the effects of numerous substances on synaptic plasticity (LTP) demonstrating the inhibitory effect of 5-HT on ' induction of LTP and pharmacologically identifying the receptors involved. It has characterized the effects of two new antagonists for 5-HT3 (Itassron) and 5-HT1A (WAY 100635) receptors on hippocampal neurotransmission and Raphe. Recently, he has focused on the mechanism of regulating the activity of serotonergic neurons of Raphe by somatodendritic receptors 5-HT1A (self-inhibition) and the potential role of self-inhibiting self-inhibition in the Death Valley Syndrome (SIDS) using a murine pathology model (Htr1AR mice that selectively over-express 5-HT1A receptors in the serotonergic neurons of Raphe, and other physiologically implicated selfinhibition mechanisms (eg 5-HT synthesis, recapping from the extracellular wall of membrane conveyors, and catabolism of serotonin). Specifically, the research aims to understand the potential role of an alteration in the mechanism of self-inhibition of serotonergic neurons in pathology, using transgenic mice bearing risk factors for human pathologies (eg mice with TpH2 activity deficits and Serotonin Membrane Conveyor -SERT Since 1985, it has received research funds from major national and local bodies (MURST, CNR, University of Florence, ECRF, Tuscany Region) and internationally (EC grants: BIO4-CT96-0752, QLG3-2002- 00809, LSHM-CT2004-503474).

Research Interest

Pharmacology