Luigi Lay
Associate Professor
Chemistry
University of Milan
Italy
Biography
Luigi Lay received his Ph.D. in Organic Chemistry in 1994 at the University of Milan, under the guidance of Prof. Giovanni Russo, working on the synthesis of oligosaccharides related to heparin/heparan sulfate glycosaminoglycans. In 1995 he moved to the Institut für Organische Chemie, University of Konstanz (Germany) as a postdoctoral fellow, where he worked on the synthesis of glycoconjugates of the lacto and neolacto series under the supervision of Prof. R. R. Schmidt. In 1996 he moved back to Milan and joined the Italian National Research Council as a researcher assistant. In 2000 he was employed as a researcher at the University of Milan (Department of Organic and Industrial Chemistry). Since 2010 he is associated professor of Organic Chemistry at the same university. His research activity currently addresses the area of the synthesis of oligosaccharides glycoconjugates endowed with immunological activity and the synthesis of sugar analogues (C-glycosides and C-phosphonates) with potential biological activity.
Research Interest
Glycoporphyrins, Saccharides as tools in biomedicine, Design and synthesis of oligosaccharides associated with pathogens and their mimics with potential immunological activity.
Publications
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Tseberlidis G, Zardi P, Caselli A, Cancogni D, Fusari M, et al. (2015) Glycoporphyrin Catalysts for Efficient C–H Bond Aminations by Organic Azides. Organometallics; 34 : 3774-3781.
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Fallarini S, Buzzi B, Giovarruscio S, Polito L, Brogioni G, et al. (2015) A Synthetic Disaccharide Analogue from Neisseria meningitidis A Capsular Polysaccharide Stimulates Immune Cell Responses and Induces Immunoglobulin G (IgG) Production in Mice When Protein-Conjugated. ACS infectious diseases; 1 : 487-496.
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Fusari M, Fallarini S, Lombardi G, Lay L. (2015) Synthesis of di-and tri-saccharide fragments of Salmonella typhi Vi capsular polysaccharide and their zwitterionic analogues. Bioorganic & medicinal chemistry; 23 : 7439-7447.
