Cristina Airoldi
Researcher
Department of Biotechnology and Biosciences
University of Milano-Bicocca
Italy
Biography
Cristina Airoldi received the degree in Industrial Biotechnology discussing an experimental thesis on the design and synthesis of bioactive compounds. She further deepened her scientific knowledge and skills attending a PhD course in Chemistry. During this period, she had the opportunity to complement the synthetic work with the NMR characterization of the interaction between the potential inhibitors she had prepared and the target protein. To this purpose, she reached a European leader group in carbohydrate-protein interaction studies (Prof. J. Jimenez-Barbero’s group, CIB, CSIC, Madrid). Having acquired such new skills, she moved to this new research field, contributing in a fundamental way to the creation and development of a new bio-NMR laboratory at the Dept. of Biotechnology and Biosciences, University of Milano-Bicocca. Now she is responsible for the scientific activity of this lab and for the maintenances of the equipment.
Research Interest
NMR spectroscopy based characterization of biologically relevant molecular interactions and recognition processes, with also the support of other techniques, such as circular dicroism, surface plasmon resonance, mass spectrometry, IR spectroscopy and atomic force microscopy, the NMR spectroscopy based conformational analysis of bioactive compounds and the application of NMR spectroscopy to the identification of metabolic markers of pathologies by metabolomics studies on cells and biofluids.
Publications
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Airoldi C., Palmioli A., D’Urzo A., Colombo S., Vanoni M., et al. (2007) Glucose-derived Ras pathway inhibitors: evidence of Ras-ligand binding and Ras-GEF (Cdc25) interaction inhibition, ChemBioChem; 8 : 1376-1379.
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Cipolla L, Fernandes MR, Gregori M, Airoldi C, Nicotra F. (2007) Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugars. Carbohydrate research; 342 : 1813-1830.
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Peri F., Airoldi C., Colombo S., Mari S., Jimenez-Barbero J., et al. (2006) Sugar-derived Ras inhibitors: Group Epitope Mapping by NMR Spectroscopy and Biological Evaluation, Eur. J. Org. Chem.; 16 : 3707-3720.
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Peri F., Airoldi C., Colombo S., Martegani E., Van Neuren A. S., et al. (2005) Design, Synthesis and Biological Evaluation of Sugar-Derived Ras Inhibitors, ChemBioChem; 6 : 1839-1848.