Sayama Koji
Professor
Graduate School of Medicine Program for Medical Sciences
Ehime University
Japan
Biography
SAYAMA Koji as Professor at Graduate School of Medicine Program for Medical Sciences in Ehime University, Japan. His Present research activities are Dermatology, Atopic dermatitis, Innate immunity
Research Interest
Dermatology, Atopic dermatitis, Innate immunity
Publications
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Expression of Fas Antigen on keratinocytes in virous and Induction of Apoptosei in Cultured Keratinocyte. The Journal of Isnestigatinl Dermatology, 103, 1994
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Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex Yuji Shirakata, Katsuto Tamai, Hiroki Nakaoka, Sho Tokumaru, Koji Sayama, Shinji Murakami, Koji Hashimoto, Journal of Dermatology, 30, 2003 02 01 , A 22-year-old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo-plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron-dense bodies. Hand contractures were released and covered with full thickness autografts of split thickness autografts. The donor site was successfully treated with cultured epidermal autografts.
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Superantigen production by Staphylococcus aureus in psoriasis Koji Sayama, Koji Sayama, K. Midorikawa, Y. Hanakawa, M. Sugai, K. Hashimoto, Dermatology, 196, 1998 04 08 , Background: Activation of T cells is believed to play a critical role in the pathogenesis of psoriasis. Recently, it has been proposed that psoriasis is a T-cell-mediated autoimmune reaction triggered by bacterial superantigen. Objective: We investigated whether patients with chronic plaque psoriasis bear superantigen-producing Staphylococcus aureus on the skin or the throat. Methods: S. aureus producing exfoliative toxin, staphylococcal enterotoxin B or toxic shock syndrome toxin 1 was isolated from the skin and throat of 100 psoriasis patients using Western blot analysis and polymerase chain reaction. Results: Only 5, 4 and 9 patients had super-antigen producing S. aureus identified on lesional skin, nonlesional skin and throat, respectively. The vast majority of patients did not bear superantigen-producing S. aureus. Conclusion: We believe that superantigens are not essential in sustaining disease activity but may, instead, be exacerbating or triggering factors for some psoriasis patients.
