Carolyn Beebe Smith
Chief
Section on Neuroadaptation and Protein MetabolismÂÂ
National Institute of Mental Health NCNP
Japan
Biography
Dr. Beebe Smith is a Senior Investigator and Chief of the Section on Neuroadaptation and Protein Metabolism of the Intramural Research Program, National Institute of Mental Health, National Institutes of Health in Bethesda, Maryland. Dr. Smith received a Ph.D. from the University of London where she studied the chemical pathology of Alzheimer's Disease with David Bowen, for which she was awarded the Queen Square Prize. She did postdoctoral training with Louis Sokoloff at NIMH, and in 1986 became a Senior Investigator within the Laboratory of Cerebral Metabolism, NIMH. In 2000 Dr. Smith was awarded an honorary degree from the University of Linköping for her work developing an in-vivo quantitative autoradiographic method for measurement of regional rates of cerebral protein synthesis in experimental animals. Dr. Smith and her team have adapted the method for use in human subjects with positron emission tomography. Dr Smith's group is currently studying mechanisms underlying brain dysfunction in fragile X syndrome and other neurodevelopmental disorders.
Research Interest
Neuroadaptation, Protein Metabolism
Publications
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Bishu S, Schmidt KC, Burlin TV, Charming MA, Horowitz L, Huang T, Liu ZH, Qin M, Vuong BK, Unterman AJ, Xia Z. Propofol anesthesia does not alter regional rates of cerebral protein synthesis measured with L-[1-11C] leucine and PET in healthy male subjects. Journal of Cerebral Blood Flow & Metabolism. 2009 May;29(5):1035-47.
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Liu ZH, Chuang DM, Smith CB. Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome. International Journal of Neuropsychopharmacology. 2011 Jun 1;14(5):618-30.
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Qin M, Entezam A, Usdin K, Huang T, Liu ZH, Hoffman GE, Smith CB. A mouse model of the fragile X premutation: effects on behavior, dendrite morphology, and regional rates of cerebral protein synthesis. Neurobiology of disease. 2011 Apr 30;42(1):85-98.
