Miles Herkenham
Chief
Section on Functional Neuroanatomy (SFN)
National Institute of Mental Health NCNP
Japan
Biography
Dr. Herkenham received a B.A. in Psychology from Amherst College in 1970 and a Ph.D. in Physiological Psychology from Northeastern University in 1975. He did postdoctoral training with Dr. W.J.H. Nauta at M.I.T. where he began a long career in neuroanatomical localization studies. Dr. Herkenham joined the NIMH IRP in 1977. In addition to being a Section Chief, he is the Acting Chief of the Laboratory of Cellular and Molecular Regulation (LCMR). He has published in the areas of neuronal tract tracing, opioid and cannabinoid receptor localization, therapeutic actions of antidepressant drugs, the neural circuitry underlying the deleterious effects of chronic psychosocial stress, the beneficial effects of environmental enrichment on mood states, immune signal molecule induction and function in the developing and adult brain, and antidepressant effects of lymphocytes adoptively transferred into naïve mice from chronically stressed mice.
Research Interest
neuroanatomy
Publications
-
Oskvig DB, Elkahloun AG, Johnson KR, Phillips TM, Herkenham M. Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response. Brain, behavior, and immunity. 2012 May 31;26(4):623-34.
-
Lehmann ML, Brachman RA, Martinowich K, Schloesser RJ, Herkenham M. Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis. Journal of Neuroscience. 2013 Feb 13;33(7):2961-72.
-
Brachman RA, Lehmann ML, Maric D, Herkenham M. Lymphocytes from chronically stressed mice confer antidepressant-like effects to naive mice. Journal of Neuroscience. 2015 Jan 28;35(4):1530-8.
