Nakajima Hidemitsu
Professor
Veterinary science
Osaka Prefecture University
Japan
Biography
College of Life, Environment, and Advanced Sciences , Graduate School of Life and Environmental Sciences, School of Life and Environmental Sciences
Research Interest
It is increasingly being realized that neurodegeneration diseases such as Alzheimer’s disease and Prion disease have common mechanism including protein aggregation. One of our goals is to elucidate the molecular mechanisms underlying in neuronal cell death with the aggregation of a pro-apoptoic protein, GAPDH, which has been identified at our labs. Currently, we are investigating the function and regulation of the aggregated GAPDH in vivo. In addition, we have special interests in the patho-physiological roles of poly(ADP-ribosyl)ation catalyzed by PARP and PARG in glia cells. These projects are going now using our techniques of cell biology and molecular biology.
Publications
-
Fujita A, Takeuchi T, Nakajima H, Nishio H, Hata F. Involvement of heterotrimeric GTP-binding protein and rho protein, but not protein kinase C, in agonist-induced Ca2+ sensitization of skinned muscle of guinea pig vas deferens. Journal of Pharmacology and Experimental Therapeutics. 1995 Jul 1;274(1):555-61.
-
Nakajima H, Nagaso H, Kakui N, Ishikawa M, Hiranuma T, Hoshiko S. Critical role of the automodification of poly (ADP-ribose) polymerase-1 in nuclear factor-κB-dependent gene expression in primary cultured mouse glial cells. Journal of Biological Chemistry. 2004 Oct 8;279(41):42774-86.
-
Nakajima H, Amano W, Fujita A, Fukuhara A, Azuma YT, Hata F, Inui T, Takeuchi T. The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death. Journal of Biological Chemistry. 2007 Sep 7;282(36):26562-74.
