Kuniya Abe
Team Leader
Technology and Development Team for Mammalian Genome Dynamic
The Institute of Physical and Chemical Research (RIKEN)
Japan
Biography
Aim of our team is to develop technologies and experimental tools/ resources for characterization of 'genotype, phenotype and epigenotype' of biological resources. Through these efforts, we would extend utilities of bioresources collected at RIKEN BRC. Based on these technologies and resources, we will establish analytical platform for analyses of dynamic nature of mammalian genome in response to changes in various environmental factors. Using this platform, we will be able to explore how environmental factors influence on development and growth of organisms, or on the onset of disease condition.
Research Interest
Molecular Biology & Genetics
Publications
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Ikeda, R., Shiura, H., Numata, K., Sugimoto, M., Kondo, M., Mise, N., Suzuki, M., Greally, J.M. and Abe, K.: “Large, male germ cell-specific hypomethylated DNA domains with unique genomic and epigenomic features on the mouse X chromosome.†DNA Research 20, 549-565. (2013)
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Shiura, H., Okamoto, A. Sasaki, H. and Abe, K.: “A novel technique for simultaneous visualization of specific DNA methylation and protein/RNA expression.†PLoS One. 9, e95750(2014)
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*Sugimoto, M., Kondo, M., Koga, Y., Shiura, H., Ikeda, R., Hirose, M., Ogura, A., Murakami, A., Yoshiki, A., Chuva de Sousa Lopes, S., Abe, K.: “A simple and robust method for establishing homogeneous mouse epiblast stem cell lines by Wnt inhibition.†Stem Cell Reports in press. (2015).
