Hiroyuki Arai
Professor
Department of Geriatrics and Gerontology
Tohoku University
Japan
Biography
Dr. Hiroyuki Arai, is a Professor of Geriatrics and Gerontology, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes Amyloid and Tau PET imaging in dementia and Alzheimer disease, Blood and cerebrospinal fluid biomarkers in dementia and Alzheimer disease, Prospective cohort study of elderly people living in temporary apartments after the Great East Japan Earthquake. Research Keywords for him are Alzheimer’s disease and dementia, molecular neuroimaging, pre-symptomatic detection and preemptic therapy, medication management in elderly people, disaster geriatric medicine.
Research Interest
positron emission tomography, disease modifying drugs, development of imaging probes, epidemiological study in earthquake-hit areas, development of ICT-based pill-box for frail elderly
Publications
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Tanaka, M., Okudaira, S., Kishi, Y., Ohkawa, R., Iseki, S., Ota, M., ... & Arai, H. (2006). Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. Journal of Biological Chemistry, 281(35), 25822-25830.
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Hattori, M., Adachi, H., Tsujimoto, M., Arai, H., & Inoue, K. (1994). Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor. Nature, 370(6486), 216-218.
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McIntyre, T. M., Pontsler, A. V., Silva, A. R., Hilaire, A. S., Xu, Y., Hinshaw, J. C., ... & Prestwich, G. D. (2003). Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARγ agonist. Proceedings of the National Academy of Sciences, 100(1), 131-136.
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Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., ... & Inoue, K. (1999). Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. Journal of Biological Chemistry, 274(39), 27776-27785.
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Hosomi, A., Arita, M., Sato, Y., Kiyose, C., Ueda, T., Igarashi, O., ... & Inoue, K. (1997). Affinity for αâ€tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS letters, 409(1), 105-108.
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Umezu-Goto, M., Kishi, Y., Taira, A., Hama, K., Dohmae, N., Takio, K., ... & Arai, H. (2002). Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J cell biol, 158(2), 227-233.
