Katsumi Dohura
Professor
Departments of Neuropathology
Tohoku University
Japan
Biography
Dr. Yoko Aoki, is a Professor of Neuropathology, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes are Development of preventive and therapeutic methods, and search for novel drug targets and novel surrogate markers for prion disease, Elucidation of molecular mechanism of prion formation, by means of chemical biology and molecular biology, Development of preventive and therapeutic methods applicable to all prion-like diseases and amyloidoses. Research Keywords for him are prion, misfolded protein, drug discovery, neuronal cell death, amyloidosis.
Research Interest
cell culture, animal experiment, chemical biology, molecular biology, pathology
Publications
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Murakami-Kubo, I., Doh-ura, K., Ishikawa, K., Kawatake, S., Sasaki, K., Kira, J. I., ... & Iwaki, T. (2004). Quinoline derivatives are therapeutic candidates for transmissible spongiform encephalopathies. Journal of virology, 78(3), 1281-1288.
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Doh-Ura, K., Iwaki, T., & Caughey, B. (2000). Lysosomotropic agents and cysteine protease inhibitors inhibit scrapie-associated prion protein accumulation. Journal of virology, 74(10), 4894-4897.
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Yoshikai, S. I., Sasaki, H., Doh-ura, K., Furuya, H., & Sakaki, Y. (1990). Genomic organization of the human amyloid beta-protein precursor gene. Gene, 87(2), 257-263.
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Yoshikai, S. I., Sasaki, H., Doh-ura, K., Furuya, H., & Sakaki, Y. (1990). Genomic organization of the human amyloid beta-protein precursor gene. Gene, 87(2), 257-263.
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Doh-ura, K., Tateishi, J., Sasaki, H., Kitamoto, T., & Sakaki, Y. (1989). Pro→ Leu change at position 102 of prinon protein is the most common but not the sole mutation related to Gerstmann-Sträussler syndrome. Biochemical and biophysical research communications, 163(2), 974-979.
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Kitamoto, T., Ohta, M., Dohura, K., Hitoshi, S., Terao, Y., & Tateishi, J. (1993). Novel missense variants of prion protein in Creutzfeldt-Jakob disease or Gerstmann-Sträussler syndrome. Biochemical and biophysical research communications, 191(2), 709-714.
