Masashi Aoki
Professor
Department of Neurology
Tohoku University
Japan
Biography
Dr. Masashi Aoki, is a Professor of Neurology, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes are Identification of molecular pathomechanisms and therapeutic development for rare and intractable neuromuscular diseases, Elucidation of underlying pathomechanisms of neuroimmunological diseases, next-generation sequencing, iPSC technology and regenerative medicine, neuromuscular pathology and biochemistry, cellular and animal model, molecular and functional imaging.
Research Interest
amyotrophic lateral sclerosis (ALS), Parkinson’s disease and related disorders, rare and intractable myopathies, multiple sclerosis (MS), neuromyelitis optica (NMO)
Publications
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Trotti, D., Aoki, M., Pasinelli, P., Berger, U. V., Danbolt, N. C., Brown, R. H., & Hediger, M. A. (2001). Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. Journal of Biological Chemistry, 276(1), 576-582.
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Sato, D. K., Callegaro, D., Lana-Peixoto, M. A., Waters, P. J., de Haidar Jorge, F. M., Takahashi, T., ... & Lino, A. M. M. (2014). Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology, 82(6), 474-481.
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Nagai, M., Aoki, M., Miyoshi, I., Kato, M., Pasinelli, P., Kasai, N., ... & Itoyama, Y. (2001). Rats expressing human cytosolic copper–zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. Journal of Neuroscience, 21(23), 9246-9254.
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Moreira, M. C., Barbot, C., Tachi, N., Kozuka, N., Uchida, E., Gibson, T., ... & Watanabe, M. (2001). The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nature genetics, 29(2), 189-193.
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Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., ... & Komure, O. (2010). Mutations of optineurin in amyotrophic lateral sclerosis. Nature, 465(7295), 223.
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Liu, J., Aoki, M., Illa, I., Wu, C., Fardeau, M., Angelini, C., ... & Bohlega, S. (1998). Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy. Nature genetics, 20(1).
