Masashi Aoki
Professor
Department of Neurology
Tohoku University
Japan
Biography
Dr. Masashi Aoki, is a Professor of Medical Genetics, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes are To investigate the pathogenesis and treatment of multiple sclerosis, To examine biomarkers of neuroimmunological diseases, Clinicopathological study of anti-AQP4- and anti-MOG-antibody-seropositive cases. Research Keywords for him are Multiple sclerosis, Neuromyelitis optica, Anti-Aquaporin 4 antibody, Myelin oligodendrocyte glycoprotein, demyelination.
Research Interest
Neuroimmunology, Biomarker, Pathology of demyelination, Disease model, HEK293
Publications
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Trotti, D., Aoki, M., Pasinelli, P., Berger, U. V., Danbolt, N. C., Brown, R. H., & Hediger, M. A. (2001). Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. Journal of Biological Chemistry, 276(1), 576-582.
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Sato, D. K., Callegaro, D., Lana-Peixoto, M. A., Waters, P. J., de Haidar Jorge, F. M., Takahashi, T., ... & Lino, A. M. M. (2014). Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology, 82(6), 474-481.
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Nagai, M., Aoki, M., Miyoshi, I., Kato, M., Pasinelli, P., Kasai, N., ... & Itoyama, Y. (2001). Rats expressing human cytosolic copper–zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. Journal of Neuroscience, 21(23), 9246-9254.
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Moreira, M. C., Barbot, C., Tachi, N., Kozuka, N., Uchida, E., Gibson, T., ... & Watanabe, M. (2001). The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nature genetics, 29(2), 189-193.
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Maruyama, H., Morino, H., Ito, H., Izumi, Y., Kato, H., Watanabe, Y., ... & Komure, O. (2010). Mutations of optineurin in amyotrophic lateral sclerosis. Nature, 465(7295), 223.
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Liu, J., Aoki, M., Illa, I., Wu, C., Fardeau, M., Angelini, C., ... & Bohlega, S. (1998). Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy. Nature genetics, 20(1).
