Noriyasu Hirasawa
Professor
Department of Pharmacotherapy
Tohoku University
Japan
Biography
Dr. Noriyasu Hirasawa, is a Professor of Pharmacotherapy, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes arePathophysiological analysis of allergy/metal allergy, Development of novel anti-allergic drugs, Pharmacogenomics for personalized medicine. Research Keywords for him are allergic dermatitis, metal allergy, anti-allergic drugs, personalized medicine, estimation of pharmacokinetics.
Research Interest
TSLP-producing cell, quantitation of metal ions, pharmacogenomics, CYP variants
Publications
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Ghosh, A. K., Hirasawa, N., Ohtsu, H., Watanabe, T., & Ohuchi, K. (2002). Defective angiogenesis in the inflammatory granulation tissue in histidine decarboxylase–deficient mice but not in mast cell–deficient mice. Journal of Experimental Medicine, 195(8), 973-982.
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Ghosh, A. K., Hirasawa, N., Niki, H., & Ohuchi, K. (2000). Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats. Journal of Pharmacology and Experimental Therapeutics, 295(2), 802-809.
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Hirasawa, N., Scharenberg, A., Yamamura, H., Beaven, M. A., & Kinet, J. P. (1995). A Requirement for Syk in the Activation of the Microtubule-associated Protein Kinase/Phospholipase A2 Pathway by FcϵR1 Is Not Shared by a G Protein-coupled Receptor. Journal of Biological Chemistry, 270(18), 10960-10967.
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Hirasawa, N., Santini, F., & Beaven, M. A. (1995). Activation of the mitogen-activated protein kinase/cytosolic phospholipase A2 pathway in a rat mast cell line. Indications of different pathways for release of arachidonic acid and secretory granules. The Journal of Immunology, 154(10), 5391-5402.
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Kamei, D., Yamakawa, K., Takegoshi, Y., Mikami-Nakanishi, M., Nakatani, Y., Oh-ishi, S., ... & Kawaguchi, H. (2004). Reduced pain hypersensitivity and inflammation in mice lacking microsomal prostaglandin e synthase-1. Journal of Biological Chemistry, 279(32), 33684-33695.
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Ohtsu, H., Tanaka, S., Terui, T., Hori, Y., Makabe-Kobayashi, Y., Pejler, G., ... & Sakurai, E. (2001). Mice lacking histidine decarboxylase exhibit abnormal mast cells. FEBS letters, 502(1-2), 53-56.
