Takaaki Akaike
Professor
Department of Environmental Health Sciences and Molecular To
Tohoku University
Japan
Biography
Dr. Takaaki Akaike, is a Professor of Environmental Health Sciences and Molecular Toxicology, at Tohoku University School of medicine. He is M.D. and Ph.D. His research themes Chemical biology of nitric oxide and reactive oxygen species and regulation of oxidative stress, Pathogenesis and epidemiology of emerging pathogen Helicobacter cinaedi. Research Keywords for him are reactive oxygen species, oxidative stress, reactive sulfur species, metabolic syndrome, molecular toxicology
Research Interest
Chemical biology, proteome, metabolome
Publications
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Sawa, T., Nakao, M., Akaike, T., Ono, K., & Maeda, H. (1999). Alkylperoxyl radical-scavenging activity of various flavonoids and other phenolic compounds: implications for the anti-tumor-promoter effect of vegetables. Journal of Agricultural and Food Chemistry, 47(2), 397-402.
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Okamoto, T., Akaike, T., Sawa, T., Miyamoto, Y., Van der Vliet, A., & Maeda, H. (2001). Activation of matrix metalloproteinases by peroxynitrite-induced protein S-glutathiolation via disulfide S-oxide formation. Journal of Biological Chemistry, 276(31), 29596-29602.
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Noguchi, Y., Wu, J., Duncan, R., Strohalm, J., Ulbrich, K., Akaike, T., & Maeda, H. (1998). Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Cancer Science, 89(3), 307-314.
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Oda, T., Akaike, T., Hamamoto, T., Suzuki, F., Hirano, T., & Maeda, H. (1989). Oxygen radical
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Akaike, T., Noguchi, Y., Ijiri, S., Setoguchi, K., Suga, M., Zheng, Y. M., ... & Maeda, H. (1996). Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proceedings of the National Academy of Sciences, 93(6), 2448-2453.
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Akaike, T., Yoshida, M., Miyamoto, Y., Sato, K., Kohno, M., Sasamoto, K., ... & Maeda, H. (1993). Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/. bul. NO (nitric oxide) through a radical reaction. Biochemistry, 32(3), 827-832.
