Yoshio Hosoi
Professor
Department of Radiation Research
Tohoku University
Japan
Biography
Dr. Yoshio Hosoi, is a Professor of Radiation Research, at Tohoku University School of medicine. She is M.D. and Ph.D. Her research themes are Radiosensitization through modification of DNA double strand breaks repair enzymes, Activity of mTOR under nutrient starvation condition and cellar radiation sensitivity, Effects of low doses of ionizing radiation. Research Keywords for her are ionizing radiation, ATM, DNA-PK, mTOR, low dose radiation
Research Interest
X-irradiation, western blotting, cell culture
Publications
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Ishii, K., Hosoi, Y., Yamada, S., Ono, T., & Sakamoto, K. (1996). Decreased incidence of thymic lymphoma in AKR mice as a result of chronic, fractionated low-dose total-body X irradiation. Radiation research, 146(5), 582-585.
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Ono, T., Ikehata, H., Nakamura, S., Saito, Y., Hosoi, Y., Takai, Y., ... & Yamamoto, K. (2000). Age-associated increase of spontaneous mutant frequency and molecular nature of mutation in newborn and old lacZ-transgenic mouse. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 447(2), 165-177.
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Hosoi, Y., Miyachi, H., Matsumoto, Y., Ikehata, H., Komura, J. I., Ishii, K., ... & Suzuki, N. (1998). A phosphatidylinositol 3-kinase inhibitor wortmannin induces radioresistant DNA synthesis and sensitizes cells to bleomycin and ionizing radiation. International journal of cancer, 78(5), 642-647.
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Komuro, Y., Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Tsuno, N., ... & Nagawa, H. (2002). The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. Cancer, 95(6), 1199-1205.
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Kitagawa, K., Hosoi, Y., Sogawa, A., Onodera, C., & Onuma, T. (1990). U.S. Patent No. 4,961,435. Washington, DC: U.S. Patent and Trademark Office.
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Hosoi, Y., Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., ... & Suzuki, N. (2004). Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. International journal of oncology, 25(2), 461-468.
