Noguchi, Hiroshi
Associate Professor
SOLID STATE PHYSICS
University of Tokyo
Japan
Biography
We study soft-matter physics and biophysics theoretically and numerically. Our main target is the physics of biomembrane and cells under various conditions. We develop membrane models and hydrodynamics simulation methods. We found the shape transitions of red blood cells and lipid vesicles in shear and capillary flows using mesoscale hydrodynamic simulations: discocyte-to-parachute, stomatocyte-to-prolate, and prolate-to-discocyte, etc. We also clarify the several fusion and fission pathways of the membrane using coarse-grained molecular simulations. In particular, the pathway via pore opening on the edge of stalk-like connection was newly found by us, and later supported by an experiment.
Research Interest
Shape transformation of cells and lipid vesicles Fusion and fission of biomembranes Dynamics of membranes out of equilibrium
Publications
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Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells: H. Shindou, H. Koso, J. Sasaki, H. Nakanishi, H. Sagara, K. M. Nakagawa, Y. Takahashi, D. Hishikawa, Y. Iizuka-Hishikawa, F. Tokumasu, H. Noguchi, S. Watanabe, T. Sasaki and T. Shimizu, J. Biol. Chem. 292 (2017) 12054--12064.
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Membrane structure formation induced by two types of banana-shaped proteins: H. Noguchi and J.-B. Fournier, Soft Matter 13 (2017) 4099.
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Acceleration and suppression of banana-shaped-protein-induced tubulation by addition of small membrane inclusions of isotropic spontaneous curvatures: H. Noguchi, Soft Matter 13 (2017) 7771-7779.
