Sin-hyeog Im
Research Fellow
Academy of Immunology and Microbiology
Institute for Basic Science
Korea
Biography
1991-1996 Senior Research Scientist, Research Center of Chong Kun Dang Pharmaceutical Company, Seoul, Korea ž2001-2003 Postdoctoral Fellow, Department of Pathology Harvard Medical School ž2004-2008 Assistant Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST) ž2008-2012 Associate Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST) ž2012-2013 Professor, School of Life Sciences, Gwangju Institute of Science and Technology (GIST) ž2014~present Professor, Division of Integrative Biosciences and Biotechnology, POSTECH
Research Interest
žRole of transcription factors (Ets1 and NFAT1) in immune regulation and tolerance žMolecular mechanism of IL-10 gene regulation in lymphocytes and dendritic cells žElucidation of the signaling pathways for IL-10 expression induced by commensal bacteria and probiotics. žElucidation of the mechanism of probiotics-induced immune modulation žCharacterization of regulatory DCs and regulatory T cells (iTreg) cells induced by probiotics žDevelopment of antigen-specific immunotherapy for autoimmune disorders (Myasthenia gravis and rheumatoid arthritis)
Publications
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Jash A, Sahoo A, Kim GC, Chae CS, Hwang JS, Kim JE, ImSH. NFAT induced permissive chromatin modification facilitates NF-κB mediated interleukin-9 (IL-9) transactivation. J Biol Chem. 2012;287(19):15445-57
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Lee IH, Kwon HK, An S, Kim D, Kim S, Yu MK, Lee JH, Lee TS, Im SH, Jon S. Imageable Antigen-Presenting Gold Nanoparticle Vaccines for Effective Cancer Immunotherapy In Vivo. Angew Chem Int Ed Engl. 2012;51(35):8800-5
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Chae CS, Kwon HK, Hwang JS, Im SH. Prophylactic effect of probiotics on the development of experimental autoimmune myasthenia gravis. PLoS One. 2012;7(12):e52119
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Kwon HK, Kim GC, Kim Y, Hwang W, Jash A, Sahoo A Nam JH, and Im SH. Amelioration of experimental autoimmune encephalomyelitis by probiotics mixture is mediated by a shift in T helper cell immune response. Clinical Immunology. 2013;146(3):217-227
