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Biomedical Sciences Experts

Phan Anh Tuan


"Division of Chemistry & Biological Chemistry School of Phys
Korea University
Korea

Biography

Professor Phan received his Bachelor’s and Master’s degrees in Physics and Mathematics from Lomonosov Moscow State University in 1995, Master’s degree in Biophysics from University of Paris-Sud in 1996, and PhD in Biophysics from École Polytechnique (France) in 1999. He took up postdoctoral and research positions at École Polytechnique (1999 - 2000) and Memorial Sloan-Kettering Cancer Center (2001 - 2006). He joined NTU in October 2006 as a faculty member in the Division of Physics and Applied Physics (PAP) in the School of Physical and Mathematical Sciences (SPMS). He was elected as a Fellow of the American Physical Society (APS) in 2014, in recognition of “his significant contributions in understanding non-canonical nucleic acid motifs, particularly the i-motif and the G-quadruplex, by developing novel NMR techniques”

Research Interest

"Professor Phan's research focuses on the use of a combination of physical, chemical, biological and computational methods to investigate and manipulate properties of biomolecules. The research goals include: (1) Structures, dynamics, interactions and functions of DNA, RNA and proteins. (2) Noncanonical structures of DNA and RNA as molecular targets against diseases. (3) Structural design and engineering of nucleic acids and proteins. (4) Application and development of methods, including Nuclear Magnetic Resonance (NMR) and other spectroscopic techniques, as well as single-molecule manipulations, for the study of biomolecular structures and dynamics."

Publications

  • Chung WJ, Heddi B, Tera M, Iida K, Nagasawa K, Phan AT. Solution structure of an intramolecular (3+ 1) human telomeric G-quadruplex bound to a telomestatin derivative. Journal of the American Chemical Society. 2013 Aug 27;135(36):13495-501.

  • Chung WJ, Heddi B, Schmitt E, Lim KW, Mechulam Y, Phan AT. Structure of a left-handed DNA G-quadruplex. Proceedings of the National Academy of Sciences. 2015 Mar 3;112(9):2729-33.

  • Heddi B, Cheong VV, Martadinata H, Phan AT. Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide–quadruplex complex. Proceedings of the National Academy of Sciences. 2015 Aug 4;112(31):9608-13.

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