Luxembourg Institute of Health
Our laboratory at Luxembourg Institute of Health is focused on how inflammation, autoimmune and allergic responses are controlled in the body’s periphery, and second, how the same factors contribute to the development of lymphoma. In particular, protein ubiquitination, signaling to NF-ĸB, control of cell death and metabolic adaptations have emerged as key mechanisms regulating immune homeostasis. How the differing signals triggered under various inflammatory conditions are integrated to ensure a coordinated immune response and maintenance of homeostasis is still poorly understood. In that respect, we analyze regulatory circuits of the adaptive and innate immune system. A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases and hematological malignancies.
Infection and Immunity