Leo Tsz On Lee
University of Macau
Leo Tsz On LEE received his Bachelor's degree from The Chinese University of Hong Kong, Hong Kong in 1997 and Ph.D. from Department of Zoology, The University of Hong Kong, Hong Kong in 2004.
Current research interests include: (1) the physiological role of class B1 GPCR in reproduction; (2) the role of GPCR dimerization in hypothalamus-pituitary-gonad (HPG) axis; and (3) the potential role of GPCR dimerization in cancer pathogenesis and progression. Those researches involve using high throughput system in cell signaling studies and using animal models, such as transgenic mice, in physiology studies.
JSW On, C Duan, BKC Chow, LTO Lee# 2015 Functional pairing of class B1 ligand-GPCR in cephalochordate provides evidence of the origin of PTH and PACAP/glucagon receptor family. Mol. Biol. Evo. 2015 Aug;32(8):2048-59.
OWH Chua; KKL Wong; BC Ko; SK Chung; BKC Chow; LTO. Lee, Role of nuclear factor of activated T-cells 5 in regulating hypertonic-mediated secretin receptor expression in kidney collecting duct cells, BBA – Gene Regulatory Mechanisms, BBA-gene regulatory mechanisms,1859(7):922-32
KG Harikumar, ML Augustine, LTO Lee, BK Chow, LJ Miller, Structure and function of cross-class complexes of G protein- coupled secretin and angiotensin 1a receptors, Journal of Biological Chemistry (in press)