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Harper-Sean  joined Amgen in 2002 as vice president, Development, and has held several leadership roles, including heading the establishment of Amgen's Medical Sciences capability, a translational medicine group focused on biomarker discovery, development, and integration into early phase clinical studies. Dr. Harper served as vice president of Global Regulatory Affairs and Safety before assuming the role of senior vice president of Global Development and Corporate Chief Medical Officer. He became executive vice president, Research and Development in February 2012. Prior to joining Amgen, Dr. Harper was senior director of clinical genomics at Merck Research Laboratories. He attended medical school at the University of California at San Francisco, completed internal medicine and gastroenterology training at the Massachusetts General Hospital, and was a postdoctoral fellow in the laboratory of Phillip A. Sharp at the Massachusetts Institute of Technology.

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