Institut Pasteur de Bangui
Alison Harrill is a scientist in the Molecular Toxicology & Genomics Group within the Biomolecular Screening Branch (BSB) of the National Toxicology Program (NTP).Harrill is leading efforts toward developing models that incorporate host genetic susceptibility into risk assessment. Genetics plays a key role in metabolism and response to drugs and chemicals, yet the systematic study of population dynamics in toxicity responses is in its infancy and understanding these dynamics may have important implications for human health risk assessment. Her current research includes investigation of population dynamics in response to drugs and chemicals, identification of gene variants that influence toxicity responses, and study of different transcriptional alterations that occur in affected tissues of sensitive versus resistant individuals. These efforts will take aim at reducing uncertainty when extrapolating risk from animal species to human populations.
Molecular Toxicology & Genomics
Cruz-Topete, D, Myers, P, Foley, J , Willis, M, Cidlowski, J. Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice. Endocrinology 2016 157(7):2759-2771
Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, et al. (2014) A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Arch Toxicol 88: 1083-1095.