Arun Kumar R. Pandiri
Cellular & Molecular Pathology
Institut Pasteur de Bangui
The Molecular Pathology Group conducts interdisciplinary research in support of the mission of the National Toxicology Program (NTP) and the NIEHS, to elucidate the pathogenesis of non-neoplastic and neoplastic lesions in various organ systems resulting from exposures to occupational and environmental toxicants/carcinogens tested by NTP. The group’s projects include descriptive toxicogenomics, retrospective studies using archival tissues, as well as prospective studies to address pathology issues relevant to NTP. In addition, the group serves on NTP study design teams to advise on issues related to molecular pathology and to provide a comparative species/translational context to studies. The goals of the Molecular Pathology Group are to: Provide mechanistic data to complement the NTP bioassays for inclusion into the NTP technical reports Use high throughput technologies to better understand chemical-induced carcinogenesis in NTP studies and partner with NTP scientists in the development of screening tools to differentiate spontaneous from chemically induced tumors Understand the molecular alterations underlying toxicities and related non-neoplastic lesions in various organ systems Collaborate with NTP and NIEHS Division of Intramural Research investigators to further characterize pathology end points Provide Laser Capture Microdissection (LCM) technology to NIEHS and NTP researchers The Molecular Pathology Group achieves its goals primarily by a combination of program-related and institute-wide collaborative research leveraging the core laboratory facilities within the NTP/NIEHS, and also through interagency collaborations and contract support.
Cellular and Molecular Pathology
Ryan KR, Cesta M, Toraason M, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL. (2016) Comparative pulmonary toxicity of inhaled metalworking fluids in rats and mice. Toxicology and Industrial Health [epub ahead of publication].
Cora MC, Gwinn W, Wilson R, King D, Waidyanatha S, Kissling GE, Brar SS, Olivera D, Blystone C and Travlos G. (2017). A black cohosh extract causes hematologic and biochemical changes consistent with a functional cobalamin deficiency in female B6C3F1/N mice. Toxicol Pathol 45, 614-623.