Frederick W. Miller
Institut Pasteur de Bangui
Frederick W. Miller, M.D., Ph.D., is Deputy Chief of the Clinical Research Branch and head of the Environmental Autoimmunity Group. The mission of the Environmental Autoimmunity Group is to understand the mechanisms for the development of autoimmune diseases so that group members can extend healthy life and reduce the burdens of illness and disability. The group conducts a broad program of clinical, translational, and basic investigations in the area of adult and pediatric autoimmune diseases. The group uses multidisciplinary approaches to understand the roles of genetic and environmental risk factors for these diseases. Group members are currently focusing investigations on the Systemic Rheumatic Diseases. These diseases include Rheumatoid Arthritis, Systemic Lupus Erythematosus, Systemic Sclerosis (Scleroderma) and the Idiopathic Inflammatory Myopathies (Dermatomyositis, Polymyositis, Inclusion Body Myositis and related Myositis Syndromes). These illnesses are heterogeneous groups of disorders defined by chronic inflammation and are prototypic autoimmune diseases.
Understanding the Mechanisms for the Development of Autoimmune Diseases
Current projects: Environmental Risk Factors for the Anti-Synthetase Syndrome - An ongoing study enrolling patients who have been diagnosed with polymyositis or dermatomyositis in the past year. The purpose of this study is to attempt to determine what environmental risk factors may lead to the development of idiopathic inflammatory myopathy (IIM) overall and in particular what risk factors lead someone to develop one type of IIM over another. Pathogenic Studies in Families with Twins or Siblings Discordant for System