Bioinformatics & Systems Biology

Bioinformatics & Systems Biology Experts

Keith Shockley

Biostatistics & Computational Biology
Institut Pasteur de Bangui

Keith Shockley


Keith Shockley, Ph.D., conducts research at the interface of environmental science and data science. He also serves as a bioinformatician for the National Toxicology Program (NTP) and an adjunct member of the Biomolecular Screening Branch. His central goal is to develop and apply computational approaches to analyze high dimensional data sets generated from quantitative high throughput screening (qHTS), functional genomics and other complex biological systems used to study environmental health. Shockley’s methodological research focuses on the construction of novel ways to detect actives and minimize false negatives in toxicity testing and environmental genomics. A major aim of this work is to build computational frameworks to determine the toxicological relevance of a chemical in qHTS experiments that take into account different variance structures that often accompany such data. In addition, he pursues suitable statistical methods to resolve differences arising from multifactorial study designs used in toxicogenomics investigations.

Research Interest

Biostatistics & Computational Biology


  • Pei Y, Peng J, Behl M, Sipes NS, Shockley KR, Rao MS, Tice RR, Zeng X. Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes. Brain Research 2016 1638(Pt A):57-73

  • Boyd WA, Smith MV, Co CA, Pirone JR, Rice JR, Shockley KR, Freedman JH. Developmental effects of the ToxCastâ„¢ Phase I and II chemicals in Caenorhabditis elegans and corresponding responses in zebrafish, rats, and rabbits. Environmental Health Perspectives 2016 124(5):586-593.

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