Genetics Experts

Kiri Hoff

Institut Pasteur de Bangui


is Chief of the Genome Integrity and Structural Biology Laboratory and head of the Mitochondrial DNA Replication Group, which studies mitochondrial diseases. Mitochondrial diseases are devastating disorders for which there is no cure and no proven treatment. About 1 in 4000 individuals is at risk of developing a mitochondrial disease sometime in their lifetime.

Research Interest

Mitochondrial diseases and mitochondrial DNA replication Disease mutations in the gene for DNA pol γ Mitochondrial toxicity induced by anti-HIV nucleoside analogs


  • Elucidation of the role of the human pol γ in induced mitochondrial toxicity caused by anti-HIV nucleoside analogs

  • Current projects: Characterization of the role of human pol γ in mtDNA mutagenesis Study of the molecular effects of disease mutations in pol γ and development of a web-based database that lists all published mutations in the POLG coding region and describes the associated diseases

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