Bioinformatics & Systems Biology

Bioinformatics & Systems Biology Experts

Michael J. Howard

Institut Pasteur de Bangui


he received his graduate and postgraduate training in medicine and biochemistry at Harvard Medical School and the National Institutes of Health. He began his career as a Principal Investigator in 1970 at NIH's National Cancer Institute (NCI). In 1991, Wilson moved to the extramural community to found a center focused in the area of genetic toxicology (DNA repair), structural biology and functional genomics. He has served in his present positions at NIEHS since the mid-1990s. Wilson has authored and co-authored more than 400 research and environmental health policy publications, and has been editor of several reference volumes. From 1996 to 2009, he served as Deputy Director and Acting Director of NIEHS.

Research Interest

Physical, biochemical, cell and molecular biology research on mammalian base excision repair enzymes—in particular, the study of gap-filling DNA synthesis in DNA repair Structural analysis to improve understanding of the fundamental mechanism of DNA synthesis and templating Investigation of cellular signaling of DNA damage


  • Current projects: Biology of Mammalian Base Excision Repair Mechanisms of Nucleic Acid Enzymes – Pol β and Mammalian Base Repair Enzymes Structure-activity Relationships of HIV-1 Reverse Transcriptase

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