Toxicology Experts

Nisha S. Sipes

Institut Pasteur de Bangui


Nisha S. Sipes, Ph.D., is a Health Science Evaluator in the Biomolecular Screening Branch of the National Toxicology Program (NTP). Her projects are focused on 1) analyzing and developing computational approaches for the Tox21 high-throughput screening dataset as well as genomics datasets, 2) developing better estimates of in vivo likelihood of exposure, 3) providing input into testing scenarios, and 4) facilitating better public understanding and use of the data. Prior to joining the NTP, Nisha spent 5 years in the National Center for Computational Toxicology at the US EPA where she analyzed ToxCast high-throughput screening data and built computational models of developmental toxicity.

Research Interest



  • Parham FM, Kohn MC, Matthews HB, DeRosa C, Portier CJ. Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls : I: Tissue:blood partition coefficients. TAP 1997; 144:340-347.

  • Freeman GB, Dill JA, Johnson, JD, Kurtz PJ, Parham FM, Mathews HB. Comparative absorption of lead from contaminated soil and lead salts by weanling fischer 344 rats. , Fundam Appl Toxicol 1996; 33:109-119.

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