Bioinformatics & Systems Biology
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Bioinformatics & Systems Biology Experts

Samuel H. Wilson


Environment
Institut Pasteur de Bangui
Mauritius

Samuel H. Wilson

Biography

Samuel H. Wilson heads the DNA Repair and Nucleic Acid Enzymology Group and holds a secondary appointment in the NIEHS Epigenetics and Stem Cell Biology Laboratory. The DNA Repair & Nucleic Acid Enzymology Group has made a number of contributions over the years to the understanding of mechanisms of DNA synthesis and, in particular, synthesis by the repair enzyme DNA polymerase β (Pol β). They identified the kinetic mechanism of this enzyme, its primary and 3 dimensional structures, and its biological roles in base excision DNA repair. This DNA repair pathway protects cells against endogenous DNA lesion including single-strand breaks.

Research Interest

Physical, biochemical, cell and molecular biology research on mammalian base excision repair enzymes—in particular, the study of gap-filling DNA synthesis in DNA repair Structural analysis to improve understanding of the fundamental mechanism of DNA synthesis and templating Investigation of cellular signaling of DNA damage

Publications

  • Current projects: Biology of Mammalian Base Excision Repair Mechanisms of Nucleic Acid Enzymes – Pol β and Mammalian Base Repair Enzymes Structure-activity Relationships of HIV-1 Reverse Transcriptase

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