Sreenivasa C. Ramaiahgari
Institut Pasteur de Bangui
reenivasa C. Ramaiahgari is a postdoctoral fellow (2014 to present) in the Molecular Toxicology and Genomics Group within the Biomolecular Screening Branch of National Toxicology Program (NTP). In his current role Ramaiahgari is involved in development and validation of metabolically competent and physiologically relevant in vitro models for high-throughput toxicology studies. Ramaiahgari has extensive experience working with various three-dimensional cell culture models of liver, kidney, breast and prostate cancer cell types. Ramaiahgari will use these advanced in vitro models and apply novel methodologies including high content imaging and data-rich toxicogenonomic approaches, e.g. Tox21 human sentinel 1500+ gene expression to study dynamic cellular stress responses upon environmental chemical exposure and extrapolate their effects on human health and disease. Ramaiahgari also contributes to several NTP in vitro screening assays.
Molecular Toxicology & Genomics
Cruz-Topete, D, Myers, P, Foley, J , Willis, M, Cidlowski, J. Corticosteroids Are Essential for Maintaining Cardiovascular Function in Male Mice. Endocrinology 2016 157(7):2759-2771
Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, et al. (2014) A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies. Arch Toxicol 88: 1083-1095.