Vesna A. Chappell
Institut Pasteur de Bangui
received certification in B.S., M.S., and Ph.D. from the University of Wisconsin-Madison, in the areas of endocrinology and reproductive physiology, specifically training in the area of mammary gland and lactation biology. She completed her post-doctoral work at the University of North Carolina's Lineberger Comprehensive Cancer Center in Chapel Hill, NC in the area of cancer biology. worked as a principal investigator at the U.S. Environmental Protection Agency's Reproductive Toxicology Division from 1998 to 2009, mentoring numerous trainees. She was a co-recipient of the 2008 Level I US Scientific and Technological Achievement Award, an EPA top honor, as well as several other awards.
Studying human disease using mice and rat models, translating internal dose in animal models to known exposure levels in U.S. residents. Investigating the developmental effects of high use herbicides and their metabolites, other compounds such as surfactants, phenolic compounds used in food storage, and common lipophilic flame retardants and pollutants. Understanding the types and ratios of environmental compounds that transfer to the infant via breast milk
Current projects: Investigate the function of hepatic and intestinal SIRT1 in lipid metabolism Study the role of SIRT1 in age-associated metabolic diseases Understand the molecular mechanisms underlying the phosphorylation regulation of SIRT1 Identification of other signaling pathways regulated by sirtuins