Vinod K. Batra
Institut Pasteur de Bangui
heads the DNA Repair and Nucleic Acid Enzymology Group and holds a secondary appointment in the NIEHS Epigenetics and Stem Cell Biology Laboratory. The DNA Repair & Nucleic Acid Enzymology Group has made a number of contributions over the years to the understanding of mechanisms of DNA synthesis and, in particular, synthesis by the repair enzyme DNA polymerase β (Pol β). They identified the kinetic mechanism of this enzyme, its primary and 3 dimensional structures, and its biological roles in base excision DNA repair. This DNA repair pathway protects cells against endogenous DNA lesion including single-strand breaks. In 1996, the group demonstrated that Pol β "knock-out" mouse fibroblast cell lines are deficient in DNA repair and in cellular protection against DNA damaging agents, thus establishing a cellular role for this enzyme. In 1985, the group discovered the amino acid sequences of human and rat Pol β through cDNA cloning; this was the first such cloning success for any of the mammalian DNA polymerases.
Physical, biochemical, cell and molecular biology research on mammalian base excision repair enzymes—in particular, the study of gap-filling DNA synthesis in DNA repair Structural analysis to improve understanding of the fundamental mechanism of DNA synthesis and templating Investigation of cellular signaling of DNA damage
Current projects: Biology of Mammalian Base Excision Repair Mechanisms of Nucleic Acid Enzymes – Pol β and Mammalian Base Repair Enzymes Structure-activity Relationships of HIV-1 Reverse Transcriptase