Prof. Dr. E.t. Van Bavel
Professor
Biomedical Engineering and Physics
AMC
Netherlands
Biography
E.T. van Bavel is one of the AMC Principal Investigators
Research Interest
he research of my group is devoted to the control of tone and remodeling of blood vessels, with a special interest in the role of physical factors (blood pressure and blood flow) in these processes and the biomechanics of the vascular wall. Our scientific objectives range from unraveling of basic mechanisms to understanding pathogenesis and consequences of notably vascular cognitive impairment, hypertension, atherosclerosis, coronary artery disease and intracranial aneurysms. We use a wide variety of approaches. These include clinical imaging modalities (in collaboration with Radiology), in vivo approaches such as rodent intracranial window, hypertension and flow restriction models, perfused arteries and arterioles of human and animal origin in organoid culture, cell-based experimental models, molecular techniques, and mathematical modeling and simulation. My group aims to combine biophysical and functional experiments with analysis of molecular parameters. Our philosophy is to perform integrative science and utilize a systems approach in order to correlate molecular mechanisms with structure and function of blood vessels and vascular networks in health and diseas
