Prof. Dr. J.j. Voorberg
Prof. dr. J.J. Voorberg is one of the AMC Principal Investigators
Within my research group we explore cellular components that are involved in maintenance of vascular homeostasis. Our research on “Cellular Haemostasis” aims to integrate biochemical and clinical research in the area of thrombosis and hemostasis, vascular biology as well as molecular and cellular immunology. Through this approach we aim to increase our current knowledge on the interactions of hemostatic proteins with the vessel wall as well as the immune system. We expect that studies in this area will result in novel therapeutic approaches for patients with vascular or haematological disorders. Our current focus of research comprises the composition and regulatory mechanism involved in release of Weibel-Palade bodies, intracellular reservoirs of hemostatic protein, angiogenic factors and inflammatory components. In related studies we aim to characterize endothelial cells derived of peripheral blood of patient with vascular or hematological abnormalities. An important topic for the next 5 years comprises the interaction of hemostatic proteins with the immune system. These studies are relevant for a better understanding of the factor contribution to inhibitor development of hemophilia A as well the auto-immune disorder thrombotic thrombocytopenic purpura (TTP).