Annemarie Meijer
Professor
Immunobiology
Leiden University
Netherlands
Biography
I am professor of Immunobiology and head of the Animal Sciences & Health research cluster. I am interested in host-pathogen interactions and work with zebrafish models for infection with intracellular bacterial pathogens, like Mycobacteria and Salmonella, to study mechanisms of host defence.
Research Interest
My research focuses on the immunobiology of host-pathogen interactions. I study mechanisms of host defence against intracellular bacterial pathogens responsible for infectious diseases like tuberculosis and typhoid fever. The causative agents of these diseases, Mycobacteria and Salmonella, parasitize one on the major cell types of the innate immune system, the macrophage. In my group, we use the optically transparent and genetically accessible early life stages of the zebrafish to study macrophage defence mechanisms in a whole organism model system.
Publications
-
Hosseini R., Lamers G.E.M., Soltani H.M., Meijer A.H., Spaink H.P. & Schaaf M.J.M. (2016), Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis, JOURNAL OF CELL SCIENCE 129(18): 3385-3395.
-
Tulotta C., He S., Chen L., Groenewoud A., Ent W. van der, Meijer A.H., Spaink H.P. & Snaar-Jagalska B.E. (2016), Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model.. In: Kawakami K., Patton E.E., Orger M. (Eds.) Zebrafish. Methods in molecular biology (Clifton, N.J.) no. 1451 New York: Springer. 155-169.
-
Benard E.L., Rougeot J.J.Y., Racz P.I., Spaink H.P. & Meijer A.H. (2016), Transcriptomic Approaches in the Zebrafish Model for Tuberculosis-Insights Into Host- and Pathogen-specific Determinants of the Innate Immune Response., Advances in genetics 95: 217-251.
