Herman Van Vlijmen
professor
Computational drug discovery
Leiden University
Netherlands
Biography
Professor Van Vlijmen (b. 1965) graduated in 1989 at Leiden University as one of the first students in Bio-Pharmaceutical Sciences. He received his PhD in Physical Chemistry from Harvard University in 1997 on the subject of “Structure, Dynamics, and Thermodynamics of Proteinsâ€. His PhD research included computational studies on protein loop prediction, protein electrostatics, and normal mode dynamics analysis of proteins withspecial applications to large virus particles. He was a post-doc researcher and an active member of the Harvard University teaching staff up to 2001. From 1996 to 2005, he worked as a scientist in Computational Drug Discovery at Biogen Idec in Cambridge, MA (USA), on the computational design of small molecules and protein therapeutics. In 2005, he moved to Tibotec Virco (a Johnson & Johnson company) in Mechelen, Belgium, where he is currently Director of Integrative Chem-Bioinformatics. Prof. Dr. Herman van Vlijmen was appointed as Professor of Computational Drug Discovery at the Division of Medicinal Chemistry in Leiden on April 15th, 2008.
Research Interest
His PhD research included computational studies on protein loop prediction, protein electrostatics, and normal mode dynamics analysis of proteins withspecial applications to large virus particles. He was a post-doc researcher and an active member of the Harvard University teaching staff up to 2001.
Publications
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Costello JC, Heiser LM, Georgii E, Gönen M, Menden MP, Wang NJ, Bansal M, Ammad-ud-din M, Hintsanen P, Khan SA, Mpindi J-P, Kallioniemi O, Honkela A, Aittokallio T, Wennerberg K, Westen GJP van, Lenselink EB, IJzerman AP, Vlijmen HWT van, NCI DREAM Community, Collins JJ, Gallahan D, Singer D, Saez-Rodriguez J, Kaski S, Gray JW & Stolovitzky G (2014), A community effort to assess and improve drug sensitivity prediction algorithms., NATURE BIOTECHNOLOGY 32: 1202–1212.
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Bansal M, Yang J, Karan C, Menden MP, Costello JC, Tang H, Xiao G, Li Y, Allen J, Zhong R, Chen B, Kim M, Wang T, Heiser LM, Realubit R, Mattioli M, Alvarez MJ, Shen Y, Westen GJP van, IJzerman AP, Lenselink EB, van Vlijmen HWT, Wegner JK, NCI-DREAM Community, Gallahan D, Singer D, Saez-Rodriguezc J, Xie Y, Stolovitzky G & Califano A (2014), A community computational challenge to predict the activity of pairs of compounds, NATURE BIOTECHNOLOGY 32: 1213–1222.
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Lenselink E.B., Jespers W., Vlijmen H.W.T. van, IJzerman A.P. & Westen G.J.P. van (2016), Interacting with GPCRs: Using Interaction Fingerprints for Virtual Screening, JOURNAL OF CHEMICAL INFORMATION AND MODELING 56(10): 2053-2060.
