Bas Pilzecker

Biography

Currently, he works on the translesion synthesis and more specifically PCNA K164R involvement in translesion synthesis and interaction with translesion synthesis polymerases. The K164R mutation leaves cells highly sensitive to alkylating agents, therefore we are also exploring PCNA K164 ubiquitination inhibition as chemosensitization strategy. During his master Cancer Genomics and Developmental Biology in Utrecht, he did internships in the Korswagen lab at the Hubrecht Institute on C. elegans and Wnt signaling He did his second intern in the Innocenti lab at the NKI/AVL, where he studied mDia2 in filopodia formation.

Research Interest

Cancer Genomics and Developmental Biology