F.j. (frank) Dekker
Associate Professor
Science and Engineering
University of Groningen
Netherlands
Biography
F.J. (Frank) Dekker, Associate professor, Faculty of Science and Engineering Chemical and Pharmaceutical Biology — Groningen Research Institute of Pharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Research Interest
Chemistry, Medicinal, Organic chemistry, enzyme kinetics, bioorthogonal reactions, cell-based studies
Publications
-
Bosch, van den, T., Leus, N. G. J., Wapenaar, H., Boichenko, A., Hermans, J., Bischoff, R., ... Dekker, F. J. (2017). A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices. Pulmonary Pharmacology & Therapeutics, 44, 88-95. DOI: 10.1016/j.pupt.2017.03.006
-
Krieger, V., Hamacher, A., Gertzen, C. G. W., Senger, J., Zwinderman, M. R. H., Marek, M., ... Hansen, F. K. (2017). Design, multicomponent synthesis and anticancer activity of a focused histone deacetylase (HDAC) inhibitor library with peptoid-based cap groups. Journal of Medicinal Chemistry, 60(13), 5493-5506. DOI: 10.1021/acs.jmedchem.7b00197
-
van den Bosch, T., Kwiatkowski, M., Bischoff, R., & Dekker, F. J. (2017). Targeting transcription factor lysine acetylation in inflammatory airway diseases. Epigenomics, 9(7), 1013-1028. DOI: 10.2217/epi-2017-0027
-
Wapenaar, H., van den Bosch, T., Leus, N. G. J., van der Wouden, P. E., Eleftheriadis, N., Hermans, J., ... Dekker, F. J. (2017). The relevance of K-i calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor. European Journal of Medicinal Chemistry, 136, 480-486. DOI: 10.1016/j.ejmech.2017.05.015
