B.j. (berend Jan) Bosch
Departement Infectieziekten en Immunologie - Virologie
Utrecht University
Netherlands
Biography
Research within the Bosch group is focused on coronaviruses. Coronaviruses are important pathogens relevant for veterinary and human health. Moreover they have demonstrated their potential to cross the species border illustrated by the recent emergence of the zoonotic SARS and MERS coronaviruses. Studying these coronaviruses at the molecular level helps to understand various aspects of coronavirus biology, including their evolution, epidemiology, pathogenesis and (cross-species) transmission as well as for the development of novel intervention strategies. We are particularly interested in coronavirus entry into the host cell and the role of the Spike protein therein. Spike glycoproteins on coronaviruses mediate binding of the virus to receptor molecules on the host cell surface, as well as subsequent cell-entry. In addition, the coronavirus Spike protein is the main target for humoral immune responses, and as such a key viral protein for development of intervention strategies.
Research Interest
Virologie
Publications
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Li, Wentao, van Kuppeveld, Frank J M, He, Qigai, Rottier, Peter J M & Bosch, Berend-Jan (14-06-2016). Cellular entry of the porcine epidemic diarrhea virus. Virus Research, 226, (pp. 117-127). Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved..
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Li, Chunhua, Li, Wentao, Lucio de Esesarte, Eduardo, Guo, Hongbo, van den Elzen, Paul, Aarts, Eduard, van den Born, Erwin, Rottier, Peter J M & Bosch, Berend-Jan (15-06-2017). Cell Attachment Domains of the Porcine Epidemic Diarrhea Virus Spike Protein Are Key Targets of Neutralizing Antibodies. Journal of Virology, 91 (12). Copyright © 2017 American Society for Microbiology..
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Li, Wentao, Luo, Rui, He, Qigai, van Kuppeveld, Frank J M, Rottier, Peter J M & Bosch, Berend-Jan (2017). Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry. Virus Research Copyright © 2017. Published by Elsevier B.V..
