C.c. (casper) Hoogenraad
Biology - Biodynamics and Biocomplexity - Cell Biology
Utrecht University
Netherlands
Biography
The primary goal of the lab is to understand how intracellular trafficking underlies neuronal development and synapse function. We particularly focus on the areas of microtubule cytoskeleton, synaptic cargo trafficking and synaptic plasticity. The research in the lab can roughly be divided in three themes: Cytoskeleton dynamics during neurodevelopment and synaptic plasticity. Motor proteins and adaptors as regulators of synaptic transport. Neuropsychiatric disorders linked to intracellular transport.
Research Interest
Cell biology and Neurobiology
Publications
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Waaijers, Selma, Muñoz, Javier, Berends, Christian, Ramalho, João J, Goerdayal, Soenita S, Low, Teck Y, Zoumaro-Djayoon, Adja D, Hoffmann, Michael, Koorman, Thijs, Tas, Roderick P, Harterink, Martin, Seelk, Stefanie, Kerver - Stumpfova, J, Hoogenraad, Casper C, Bossinger, Olaf, Tursun, Baris, van den Heuvel, Sander, Heck, Albert J R & Boxem, Mike (09.08.2016). A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biology, 14.
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Frese, Christian K, Mikhaylova, Marina, Stucchi, Riccardo, Gautier, Violette, Liu, Qingyang, Mohammed, Shabaz, Heck, Albert J R, Altelaar, A F Maarten & Hoogenraad, Casper C (07.02.2017). Quantitative Map of Proteome Dynamics during Neuronal Differentiation. Cell Reports, 18 (6), (pp. 1527-1542) (16 p.). Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved..
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van Riel, Wilhelmina E, Rai, Ankit, Bianchi, Sarah, Katrukha, Eugene A, Liu, Qingyang, Heck, Albert Jr, Hoogenraad, Casper C, Steinmetz, Michel O, Kapitein, Lukas C & Akhmanova, Anna (2017). Kinesin-4 KIF21B is a potent microtubule pausing factor. eLife, 6 (30 p.).
