P. (piet) Gros
Chemistry - Biomolecular Sciences - Crystal and Structural C
Utrecht University
Netherlands
Biography
Piet Gros studies the molecular mechanisms of recognition and regulation that underlie biological processes. His major expertise is in the area of protein crystallography methodology and its application to large human plasma proteins and cell-surface receptors and membrane proteins. Regulation in cells and organisms is achieved by the interplay of proteins acting in concert to achieve a control over time and space. In many cases, the proteins involved are multi-domain proteins that function in large complexes. This enables a collective set of proteins to form a protein machinery that carries out elementary regulatory functions such as initiation, amplification, localization and inhibition. His research goal is to reveal the mechanisms of tertiary and quaternary-induced activation in multi-domain proteins and multi-protein complexes that underlie the recognition and regulation processes.
Research Interest
Biomacromolecular Crystallography
Publications
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Sharp, Thomas H., Koster, Abraham J. & Gros, Piet (2016). Imaging complement activation step-by-step on liposomes by phase-plate cryo-electron tomography. Immunobiology, 221 (10), (pp. 1194-1195)
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Sharp, Thomas H., Koster, Abraham J. & Gros, Piet (05.04.2016). Heterogeneous MAC Initiator and Pore Structures in a Lipid Bilayer by Phase-Plate Cryo-electron Tomography. Cell Reports, 15 (1), (pp. 1-8) (9 p.).
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De Nardis, Camilla, Lössl, Philip, Van Den Biggelaar, Maartje, Madoori, Pramod K., Leloup, Nadia, Mertens, Koen, Heck, Albert J R & Gros, Piet (20.01.2017). Recombinant expression of the full-length ectodomain of LDL receptor-related protein 1 (LRP1) unravels phdependent conformational changes and the stoichiometry of binding with receptor-associated protein (RAP). Journal of Biological Chemistry, 292 (3), (pp. 912-924) (13 p.).
