Rj (roland) Pieters
Pharmaceutical Sciences - Molecular Pharmacy
Utrecht University
Netherlands
Biography
We make new compounds through organic synthesis that can block or detect disease-causing processes, with high affinity and selectivity. In many cases, it involves protein-carbohydrate interactions. Multivalence is an important theme and is used to enhance the working power of often low-binding carbohydrates. Boom-like structures (dendrimers) are used to make systems multivalent, but also nanoparticles and array surfaces are investigated.
Research Interest
Chemical biology of multivalent systems
Publications
-
Shi, Jie, TomaÅ¡iÄ, Tihomir, Sharif, Suhela, Brouwer, Arwin J, Anderluh, Marko, Ruijtenbeek, Rob & Pieters, Roland J (05.06.2017). Peptide Microarray Analysis of the Cross-Talk Between O-GlcNAcylation and Tyrosine Phosphorylation . FEBS Letters This article is protected by copyright. All rights reserved ..
-
Sevsek, Alen, Šrot, Luka, Rihter, Jakob, Čelan, Maša, Ufford, Linda Quarles, Moret, Ed E, Martin, Nathaniel I & Pieters, Roland J (2017). N-Guanidino Derivatives of 1,5-Dideoxy-1,5-imino-d-xylitol are Potent, Selective, and Stable Inhibitors of β-Glucocerebrosidase . ChemMedChem , 12 (7), (pp. 483-486). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim ..
-
Sharif, Suhela, Shi, Jie, Mostafa, Bourakba, Ruijtenbeek, Rob & Pieters, Roland J (2017). Measurement of O-GlcNAc cleavage at OGA and cell lysates on a peptide microarray . Analytical Biochemistry Copyright © 2017. Published by Elsevier Inc ..
