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Bauke Albada

Professor
Department of Agrotechnology and Food Sciences
Wageningen University
Netherlands

Biography

My research explores the boundaries between Chemistry and Biology. Inspired by nature, my group develops novel approaches to: site-selectively modify proteins, identify the molecular mechanism by which omega-3 fatty acids interact with human inflammation pathways, functionalizes a wide variety of surfaces with biosensors or biomimetic catalysts, explores novel methods to combat bacterial infections. We collaborate with various groups within the Wageningen University & Research community, other groups in The Netherlands and abroad. My work has been published in leading chemistry journals like J. Am. Chem. Soc., Angew. Chem., Chem. Sci., and J. Org. Chem.. I obtained my Ph.D. degree from the Utrecht University (The Netherlands) under supervision of prof. dr. Rob M. J. Liskamp, for my work on peptide-based mimics of enzyme active sites, and their application in catalysis and medicinal concepts. During my post-doctoral studies in the group of prof. dr. Nils Metzler-Nolte in Bochum (Ruhr University Bochum, Germany), I studied organometallic-peptide conjugates that prooved to have unparalleled antibacterial activity, and developed several novel methods for the conjugation of bioactive peptides and organometallic moieties (21 publications). My most recent activities, in the laboratory of prof. dr. Itamar Willner in Jerusalem (The Hebrew University of Jerusalem, Israel), were directed at the development of DNA architectures as novel catalytic entities and sensing modules.

Research Interest

Analytical chemistry Antimicrobial peptides Chemistry DNA Inorganic chemistry Organic chemistry Peptide antibiotics Peptides Synthetic peptides

Publications

  • The Chemoselective Reactions of Tyrosine-Containing G-Protein-Coupled Receptor Peptides with [Cp*Rh(H2O)3](OTf)2, Including 2D NMR Structures and the Biological Consequences H. Bauke Albada, Florian Wieberneit, Ingrid Dijkgraaf, Jessica H. Harvey, Jennifer L. Whistler, Raphael Stoll, Nils Metzler-Nolte, and Richard H. Fish (2012) J. Am. Chem. Soc.

  • Small Cationic Antimicrobial Peptides Delocalize Peripheral Membrane Proteins Michaela Wenzel, Alina Iulia Chiriac, Andreas Otto, Dagmar Zweytick, Caroline May, Catherine Schumacher, Ronald Gust, H Bauke Albada, Maya Penkova, Ute Krämer, Ralf Erdmann, Nils Metzler-Nolte, Suzana K Straus, Erhard Bremer, Dörte Becher, Heike Brötz-Oesterhelt, Hans-Georg Sahl, Julia Elisabeth Bandow (2014) Proc. Natl. Acad. Sci., USA

  • Programmed Synthesis by Stimuli-Responsive DNAzyme-Modified Mesoporous SiO2 Nanoparticles Dora Balogh, Miguel Angel Aleman Garcia, H. Bauke Albada, Itamar Willner (2015) Angew. Chem.

  • Nucleoapzymes: Hemin/G-Quadruplex DNAzyme–Aptamer Binding Site Conjugates with Superior Enzyme-like Catalytic Functions Eyal Golub, H. Bauke Albada, Wei-Ching Liao, Yonatan Biniuri, and Itamar Willner (2016) J. Am. Chem. Soc.

  • Organometallic–Peptide Bioconjugates: Synthetic Strategies and Medicinal Applications Bauke Albada and Nils Metzler-Nolte (2016) Chem. Rev.

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