Irwin Gelman

Biography

Dr. Gelman is the John and Santa Palisano Chair of Cancer Genetics at Roswell Park Cancer Institute, as well as RPCI Comprehensive Cancer Center Genetics Program Leader, Chair of the RPCI Cell and Molecular Biology Academic Department of SUNY at Buffalo, a Professor of Oncology and the Director of the Genomics and shRNA Core Resource Labs at RPCI. He received his BA from Wesleyan University, MA, MPh and PhD degrees in Microbiology from Columbia University and was a Postdoctoral Associate in the laboratory of Dr. Hidesaburo Hanafusa at The Rockefeller University. After 13 years as an Assistant and Associate Professor in Microbiology and Infectious Diseases at Mount Sinai School of Medicine, Dr. Gelman came to RPCI in 2003. His research has focused on the roles of Src family kinases in promoting oncogenic progression, especially in relation to metastasis formation. His lab has expertise in identifying metastasis suppressor and inducer genes using genetic screens, dissecting Src/FAK-regulated pathways in oncogenesis, mouse models of the role of Src in castration recurrent prostate cancer, identification of Src-regulated androgen receptor gene expression signatures that drive prostate cancer malignancy. In conjunction with Athenex, LLC, he has participated in the characterization of small molecule inhibitors of Src in preventing or treating recurrent/metastatic cancer in preclinical models. Dr. Gelman has been a member on multiple NIH and DoD grant study sections and integration panels, and is currently an Associate Editor of Cancer Research.

Research Interest

 Cancer