Dr Clare Marie Reynolds

Biography

The links between obesity, insulin resistance and immune function have provided the basis for the emerging field of immuno-metabolism. While evidence of immune cell infiltration and increased expression of inflammatory mediators such as TNFα and IL-1β have provided many clues as to mechanisms through which “meta-inflammation” instigates metabolic dysfunction, there are many questions which remain unanswered, particularly in relation to developmental programming of health and disease. Despite a wide range of research in the area of developmental programming of metabolic dysfunction, the role of meta-inflammation has not been comprehensively assessed. Using my extensive expertise in adipose tissue biology and immuno-metabolism, my current research at the Liggins Institute sets out to bridge the gaps in knowledge between developmental programming and metabolic inflammation. My current focus centres on adipose tissue biology and the female reproductive system. Currently supported by an HRC Sir Charles Hercus Research fellowship and an Emerging Researcher Research GrantThe links between obesity, insulin resistance and immune function have provided the basis for the emerging field of immuno-metabolism. While evidence of immune cell infiltration and increased expression of inflammatory mediators such as TNFα and IL-1β have provided many clues as to mechanisms through which “meta-inflammation” instigates metabolic dysfunction, there are many questions which remain unanswered, particularly in relation to developmental programming of health and disease. Despite a wide range of research in the area of developmental programming of metabolic dysfunction, the role of meta-inflammation has not been comprehensively assessed. Using my extensive expertise in adipose tissue biology and immuno-metabolism, my current research at the Liggins Institute sets out to bridge the gaps in knowledge between developmental programming and metabolic inflammation. My current focus centres on adipose tissue biology and the female reproductive system. Currently supported by an HRC Sir Charles Hercus Research fellowship and an Emerging Researcher Research Grant

Research Interest

Adipose tissue biology - Maternal obesity - Pregnancy - Type 2 diabetes - Reproductive function - Developmental programming of health and disease - Metabolic inflammation