Mark Hampton
Professor
Pathology
Otago University
New Zealand
Biography
Professor Mark Hampton Investigator, Centre for Free Radical Research PhD (Otago) MSc(Hons) (Canterbury)
Research Interest
Oxidants (also called reactive oxygen species or free radicals) are continuously generated in our body, and we rely on sophisticated antioxidant systems to prevent them from causing damage. However, oxidants also have beneficial roles. They can act as signalling molecules that regulate a number of life and death pathways in cells, and they are generated by the immune system to fight microbes. My research is focused on how understanding how cells sense and respond to oxidants, and how these pathways might be modulated to prevent and treat human disease.
Publications
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Bayer, S. B., Low, F. M., Hampton, M. B., & Winterbourn, C. C. (2016). Interactions between peroxiredoxin 2, hemichrome and the erythrocyte membrane. Free Radical Research, 50(12), 1329-1339. doi: 10.1080/10715762.2016.1241995
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Spencer, E. S., O'Connor, K. M., & Hampton, M. B. (2017). Isothiocyanates trigger early disruption of mitochondrial function in cells overexpressing Bcl-2. Free Radical Biology & Medicine, 108(Suppl. 1), (pp. S51). doi: 10.1016/j.freeradbiomed.2017.04.185
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Dagnell, M., Pace, P. E., Cheng, Q., Frijhoff, J., Östman, A., Arnér, E. S. J., Hampton, M. B., & Winterbourn, C. C. (2017). Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure. Journal of Biological Chemistry. Advance online publication. doi: 10.1074/jbc.M117.793745
