Brian Monk
Associate Professor
Department of Oral Sciences
University of Otago
New Zealand
Biography
Brian Monk is an Associate Professor in Department of Oral Sciences at University of Otago, New Zealand. Dr. Monk uses molecular genetic manipulation of yeast and bacterial systems to express drug targets for effective screening of compound libraries. He is the author of several articles published in reputed journals.
Research Interest
Dr Monk uses molecular genetic manipulation of yeast and bacterial systems to express drug targets for effective screening of compound libraries. Most of the antifungal targets he has developed are membrane proteins. These include essential P-type ATPases, fungal glucan synthase, cytochrome P450 enzymes and drug efflux pumps. Other targets include fungal transcription factors and enzymes involved in fungal riboflavin biosynthesis. Related research interests include defining and overcoming mechanisms of echinocandin, anthelmintic and antimalarial resistance, expressing human drug targets for drug screening, and equipping yeast biofactories with efflux pumps to improve productivity by protecting against toxic substrates, products, and metabolites.
