Greg Cook
Professor
Microbiology & Immunology
University of Otago
New Zealand
Biography
Research in my laboratory is focused on developing bacterial metabolism and energetics as a new target space for drug development to combat bacterial pathogens (Mycobacterium tuberculosis) and environmental microorganisms that contribute significantly to greenhouse gas emissions. The goal of this research is to produce a new class of antibiotics that specifically target the metabolism of microorganisms in their environment. This research includes bacteriology, biochemistry, protein purification and crystallography, PC3 laboratory experiments, molecular biology and genetics.
Research Interest
Microbial physiology and biochemistry, antimicrobial resistance, drug discovery, molecular microbiology, structural biology
Publications
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Weimar, M.R., Cheung, J., Dey, D., McSweeney, C., Morrison, M., Kobayashi, Y., Whitman, W.B., Carbone, V., Schofield, L.R., Ronimus, R.S. and Cook, G.M. Development of multi-well plate methods using pure cultures of methanogens to identify new inhibitors for suppressing ruminant methane emissions. Applied and Environmental Microbiology May 19. pii: AEM.00396-17. doi: 10.1128/AEM.00396-17. [Epub ahead of print] (2017)
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Kalia, N.P., Hasenoehrl, E.J., Ab Rahman, N.B., Koh, V.H., Ang, M.L., Sajorda, D.R., Hards, K., Grüber, G., Alonso, S., Cook, G.M., Berney, M. and Pethe, K. Exploiting the synthetic lethality between terminal respiratory oxidases to kill Mycobacterium tuberculosis and clear host infection. Proceedings of the National Academy of Sciences of the United States of America 114:7426-7431 (2017)
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Cook, G.M.,Hards, K., Dunn, E., Heikal, A., Nakatani, Y., Greening, C., Crick, D.C., Fontes, F.L., Pethe, K., Hasenoehrl, E. and Berney, M. OXPHOS as a target space for tuberculosis: success, caution, and future directions. In Tuberculosis and the Tubercle Bacillus Third Edition, Edited by William R. Jacobs, Jr., Helen McShane, Valerie Mizrahi and Ian Orme. American Society for Microbiology, Washington, DC. Microbiol Spectrum 5(2): doi:10.1128/microbiolspec.
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Cook, G.M.,Hards, K., Dunn, E., Heikal, A., Nakatani, Y., Greening, C., Crick, D.C., Fontes, F.L., Pethe, K., Hasenoehrl, E. and Berney, M. OXPHOS as a target space for tuberculosis: success, caution, and future directions. In Tuberculosis and the Tubercle Bacillus Third Edition, Edited by William R. Jacobs, Jr., Helen McShane, Valerie Mizrahi and Ian Orme. American Society for Microbiology, Washington, DC. Microbiol Spectrum 5(2): doi:10.1128/microbiolspec.
