Greg Giles

Biography

  Dr. Greg Giles is currently working as a Senior Lecturer in the Department of Pharmacology and Toxicology, University of Otago School of Biomedical Sciences , New Zealand. His research interests includes Medicinal Chemistry, Drug Design, Free Radical Biology, Nitric Oxide, Antioxidants, Cancer, Stroke, Heart Disease, Mental Dementia. He is serving as an editorial member and reviewer of several international reputed journals. Dr. Greg Giles is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Medicinal Chemistry, Drug Design, Free Radical Biology, Nitric Oxide, Antioxidants, Cancer, Stroke, Heart Disease, Mental Dementia.

Research Interest

 The Giles Group is investigating biological reduction and oxidation (REDOX) reactions, a wide-ranging field that encompasses energy metabolism, signal transduction pathways, enzyme function and the chemical defence mechanism of the body's immune system. Each cell in the body has to sustain a reducing environment for normal physiological function. This is achieved by maintaining an antioxidant defence network which utilises enzymes, vitamins and cellular reductants. If this defence is breached then oxidative damage can occur throughout the cell, resulting in impaired function and ultimately cell death. This event, termed oxidative stress, is implicated in the pathologies of many diseases including cancer, aging, diabetes, cardiovascular dysfunction and dementia. They are actively involved in drug discovery projects which look at new ways to protect cells from oxidative damage and so provide urgently needed therapies for clinical use.