S. W. Lowe

Biography

  Dr. Scott W. Lowe, Ph.D. serves as a Scientific Founder of Blueprint Medicines Corporation. Dr. Lowe is a Co-Founder of ORIC Pharmaceuticals Inc. He serves as Professor of Cold Spring Harbor Laboratory. Dr. Lowe joined CSHL in 1995. He served as the Deputy Director of the Cold Spring Harbor Laboratory (CSHL) Cancer Center and leader of a multidisciplinary team of cancer researchers and clinicians that are working toward finding ways to control cancers in more powerful yet less toxic ways. He was accepted into the CSHL Fellows Program, focusing on apoptosis, a genetic program used in many chemotherapies that moves cells to destroy themselves. Dr. Lowe moved quickly from the Fellows Program to assistant, then associate investigator and was named a full professor at CSHL in 2000. In 2001, he became the deputy director of the Cancer Center and in 2005, he was named an investigator of the Howard Hughes Medical Institute. His research has made important contributions to the understanding of the p53 tumor suppressor pathway, as well as the processes of multi-step carcinogenesis, cellular senescence and tumor-cell drug resistance. Dr. Lowe's research focuses on understanding the processes that allow normal cells to resist becoming cancerous and how defects in these processes lead to cancer development and alter the response of cancer cells to chemotherapy. He serves as the Chairman of Scientific Advisory Board of PMV Pharmaceuticals, Inc. He is Chair of the Geoffrey Beene Cancer Research Center. He also is interested in revealing how cancer-causing genes create biological dependencies that may be targeted therapeutically. He has been a Member of Scientific Advisory Board at Petra Pharma Corporation since July 27, 2017. He serves as a Member of the Scientific Advisory Board of Constellation Pharmaceuticals, Inc. and Blueprint Medicines Corporation. He is the Chair of the Cancer Biology and Genetics Program at Memorial Sloan-Kettering Cancer Center. Dr. Lowe has received several awards, including a Sydney Kimmel Foundation Scholar Award, a Rita Allen Foundation Scholar Award, the AACR Outstanding Investigator Award, the AACR-NFCR Professorship in Basic Cancer Research and the Paul Marks Prize for Cancer Research. Dr. Lowe received a B.S. in biochemistry from the University of Wisconsin-Madison and a Ph.D. in biology from the Massachusetts Institute of Technology. He holds post-doctoral work at the MIT Center for Cancer Research.

Research Interest

Cancer and Oncology